The Community Access National Network (CANN) Monkeypox (MPV) Response Project for People Living with HIV is designed to provide a national, state-by-state, patient-facing resource on policies, programs, activities, and news regarding the United States' response to the MPV outbreak that began in May 2022. The project primarily aims to help patients living with HIV understand, engage, and advocate on matters of public health being influenced by MPV in the United States. Because poorly executed and delayed public health programs are poised for MPV to become endemic in the United States and is disproportionately impacting people living with HIV, a consolidated resource which reflects a patient's ability to navigate these complex systems is necessary. Recognizing both strengths and weaknesses across public health programs empowers patients to self-advocate for efficient and effective policies and programs, a lesson well learned in HIV advocacy.